Scientific Publications

Mukherjee R, Bhattacharya A, Mello-Vieira J, Kuncha SK, Hoffmann M, Gonzalez A, … Dikic I. (2024). "Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis". Autophagy, 1–17. DOI: 10.1080/15548627.2024.2404375

Cheng Y, Mello-Vieira J, Covarrubias-Pinto A, Gonzalez A, Kuncha SK, Kew C,....., Ivan Dikic. (2024) "Intracellular lipopolysaccharide regulates ER remodeling upon bacterial infection" bioRxiv preprint. DOI: 10.1101/2024.07.25.605133 

Berkane R, Ho-Xuan H, Glogger M, Sanz-Martinez P, Brunello L, Glaesner T, Kuncha SK,......, Alexandra Stolz. (2023)"The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways" Nat Commun.14:1. DOI: 10.1038/s41467-023-44101-5

González A*, Covarrubias-Pinto A*, Bhaskara RM, Glogger M, Kuncha SK ,…., Dikic I. (2023) “ Ubiquitination regulates ER-phagy and remodeling of the endoplasmic reticulum ” Nature. DOI: 10.1038/s41586-023-06089-2

Bhattacharya A, Mukherjee R, Kuncha SK, Brunstein M, Rajeswari Rathore R, Junek S., Münch C, Dikic I. (2023) “A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins” Nature Cell Biology. DOI: 10.1038/s41556-023-01125-9; bioRxiv preprint .

Sivakumar K, Venkadasamy VL, Amudhan G, Ann KJ, Goud GK, Nayani K, Gogoi J,  Kuncha SK , Mainkar PS, Kruparani SP, Sankaranarayanan R. (2023) “ Design principles and functional basis of enantioselectivity of alanyl-tRNA synthetase and a chiral proofreader during protein biosynthesis” Nucleic Acids Research . gkad205. DOI: 10.1093/nar/gkad205

Gogoi G, Bhatnagar A, Ann KJ, Pottabathini S, Singh R, Mazeed M, Kuncha SK , Kruparani SP, Sankaranarayanan R. (2022) “Switching a conflicted bacterial DTD-tRNA code is essential for the emergence of mitochondria” Sci. Adv. 8(2).eabj7307. DOI: 10.1126/sciadv.abj7307

Kuncha SK , Venkadasamy VL, Amudhan G, Dahate P, Kola SR, Pottabathini S, Kruparani SP, Shekar PC, Sankaranarayanan R. (2020) “ Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia” Elife . 9.e58118. DOI: 10.7554/eLife.58118 (Featured in The Hindu daily newspaper: “ A sponge-like single-cell ancestor ” written by Prof. D. Balasubramanian).

Kuncha SK , Kruparani SP, Sankaranarayanan R. (2019) "Chiral checkpoints during protein biosynthesis". J. Biol. Chem. 294:16535-16548. DOI: 10.1074/jbc.REV119.008166 .

Kuncha SK* , Suma K*, Pawar KI, Gogoi J, Routh SB, Pottabathini S, Kruparani SP, Sankaranarayanan R. (2018b) " A discriminator code–based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria" eLife . 7.e28232. DOI: 10.7554/eLife.38232 .

Kuncha SK* , Mazeed M*, Singh R, Kattula B, Routh SB, Sankaranarayanan R. (2018a) “ A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia ”. Nat Commun. 9:522. DOI: 10.1038/s41467-017-02204-w .

Pawar KI, Suma K, Seenivasan A, Kuncha SK , Routh SB, Kruparani SP, Sankaranarayanan R. (2017) “ Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS ”. eLife . 6.e24001. DOI: 10.7554/eLife.24001 .

Routh SB, Pawar KI, Ahmad S, Singh S, Suma K, Kumar M, Kuncha SK , Yadav K, Kruparani SP, Sankaranarayanan R. (2016) “ Elongation factor Tu prevents misediting of Gly-tRNA(Gly) caused by the design behind the chiral proofreading site of D-aminoacyl-tRNA deacylase ”. PLoS Biol . 14(5):e1002465. DOI: 10.1371/journal.pbio.1002465 .

Ahmad S, Muthukumar S, Kuncha SK , Routh SB, Yerabham AS, Hussain T, Kamarthapu V, Kruparani SP, Sankaranarayanan R. (2015) “ Specificity and catalysis hardwired at the RNA–protein interface in a translational proofreading enzyme ”.
Nat Commun . 6:7552. DOI: 10.1038/ncomms8552 .

Sen S, Kamma SR, Gundla R, Adepally U,  Kuncha SK , Thirnathi S, Prasad UV. (2013) “ A reagent-based DOS strategy via Evans chiral auxiliary: highly stereoselective Michael reaction towards optically active quinolizidinones, piperidinones and pyrrolidinones” . RSC Adv. 3:2404-2411. DOI: 10.1039/C2RA22115B .

COVID-19 Related

Gokulan CG*, Kiran U*, Kuncha SK* , Mishra RK. (2021) “Temporal stability and detection sensitivity of the dry swab-based diagnosis of SARS-CoV-2”. J. Biosci. 46:95. DOI: 10.1007/s12038-021-00216-9 .

Manupati H*, Kiran U*, Kuncha SK* , Kopperi H*, Gokulan CG*, Mohan SV, Mishra RK. (2021) "Comprehensive Surveillance of SARS-CoV-2 Spread Using Wastewater-based Epidemiology Studies". Science of the Total Environment . 768:144704 DOI: 10.1016/j.scitotenv.2020.144704 .

Kiran U*, Gokulan CG*, Kuncha SK* , Vedagiri D, Chander BT, Sekhar AV, Dontamala S, Reddy AL, Suchitra D, Tallapaka KB, Mishra RK, Harshan KH. (2020) “Easing diagnosis and pushing the detection limits of SARS-CoV-2”. Biology Methods and Protocols , Oxford University Press. DOI: 10.1093/biomethods/bpaa017 .

(* indicates equal contribution)